Ipsilateral sequential arm movements after unilateral subthalamic deep‐brain stimulation in patients with Parkinson's disease
Identifieur interne : 001667 ( Main/Corpus ); précédent : 001666; suivant : 001668Ipsilateral sequential arm movements after unilateral subthalamic deep‐brain stimulation in patients with Parkinson's disease
Auteurs : Rocco Agostino ; Loredana Dinapoli ; Nicola Modugno ; Ennio Iezzi ; Bruno Gregori ; Vincenzo Esposito ; Pantaleo Romanelli ; Alfredo BerardelliSource :
- Movement Disorders [ 0885-3185 ] ; 2008-09-15.
English descriptors
Abstract
Unilateral STN‐DBS significantly improves the performance of contralateral sequential arm movements. Whether unilateral STN‐DBS also improves ipsilateral sequential movement is unclear. In this study in unmedicated parkinsonian patients, we tested the effect of unilateral STN‐DBS on the performance of ipsilateral sequential movements and compared it with the performance of contralateral sequential movements. Three‐dimensional movements were recorded with the ELITE system and three kinematic variables were considered: total movement time (TMT), total inter‐onset latency (IOL), and spatial accuracy. Unilateral STN‐DBS significantly decreased TMT in the contralateral arm and only tended to do so also in the ipsilateral arm, whereas it significantly decreased IOL and worsened spatial accuracy only on the contralateral side. Before unilateral STN‐DBS a positive correlation was present between the clinical impairment and the TMTs in the contralateral and ipsilateral sides. After unilateral STN‐DBS the UPDRS scores improved in the contralateral and to a lesser extent also in the ipsilateral side. Correlation analysis between clinical and kinematic data showed no differences between the contralateral and ipsilateral sides. Our kinematic findings show that after STN‐DBS parkinsonian patients' performance of a sequential motor task improves significantly on the contralateral but only tended to do so on the ipsilateral side. Ipsilateral changes can be explained by the observation that the output structures of the basal ganglia send large ipsilateral and less dense contralateral projections to the thalamus. © 2008 Movement Disorder Society
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DOI: 10.1002/mds.22203
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Whether unilateral STN‐DBS also improves ipsilateral sequential movement is unclear. In this study in unmedicated parkinsonian patients, we tested the effect of unilateral STN‐DBS on the performance of ipsilateral sequential movements and compared it with the performance of contralateral sequential movements. Three‐dimensional movements were recorded with the ELITE system and three kinematic variables were considered: total movement time (TMT), total inter‐onset latency (IOL), and spatial accuracy. Unilateral STN‐DBS significantly decreased TMT in the contralateral arm and only tended to do so also in the ipsilateral arm, whereas it significantly decreased IOL and worsened spatial accuracy only on the contralateral side. Before unilateral STN‐DBS a positive correlation was present between the clinical impairment and the TMTs in the contralateral and ipsilateral sides. After unilateral STN‐DBS the UPDRS scores improved in the contralateral and to a lesser extent also in the ipsilateral side. Correlation analysis between clinical and kinematic data showed no differences between the contralateral and ipsilateral sides. Our kinematic findings show that after STN‐DBS parkinsonian patients' performance of a sequential motor task improves significantly on the contralateral but only tended to do so on the ipsilateral side. Ipsilateral changes can be explained by the observation that the output structures of the basal ganglia send large ipsilateral and less dense contralateral projections to the thalamus. © 2008 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Rocco Agostino MD</name><affiliations><json:string>Neuromed Institute, “Sapienza,” University of Rome, Italy</json:string></affiliations></json:item><json:item><name>Loredana Dinapoli PhD</name><affiliations><json:string>Neuromed Institute, “Sapienza,” University of Rome, Italy</json:string></affiliations></json:item><json:item><name>Nicola Modugno MD</name><affiliations><json:string>Neuromed Institute, “Sapienza,” University of Rome, Italy</json:string></affiliations></json:item><json:item><name>Ennio Iezzi MD</name><affiliations><json:string>Neuromed Institute, “Sapienza,” University of Rome, Italy</json:string><json:string>Department of Neurological Sciences, “Sapienza,” University of Rome, Italy</json:string></affiliations></json:item><json:item><name>Bruno Gregori MD</name><affiliations><json:string>Department of Neurological Sciences, “Sapienza,” University of Rome, Italy</json:string></affiliations></json:item><json:item><name>Vincenzo Esposito MD</name><affiliations><json:string>Neuromed Institute, “Sapienza,” University of Rome, Italy</json:string><json:string>Department of Neurological Sciences, “Sapienza,” University of Rome, Italy</json:string></affiliations></json:item><json:item><name>Pantaleo Romanelli MD</name><affiliations><json:string>Neuromed Institute, “Sapienza,” University of Rome, Italy</json:string></affiliations></json:item><json:item><name>Alfredo Berardelli MD</name><affiliations><json:string>Neuromed Institute, “Sapienza,” University of Rome, Italy</json:string><json:string>Department of Neurological Sciences, “Sapienza,” University of Rome, Italy</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>subthalamic nucleus</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>deep brain stimulation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>sequential arm movements</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item></subject><articleId><json:string>MDS22203</json:string></articleId><language><json:string>eng</json:string></language><abstract>Unilateral STN‐DBS significantly improves the performance of contralateral sequential arm movements. Whether unilateral STN‐DBS also improves ipsilateral sequential movement is unclear. In this study in unmedicated parkinsonian patients, we tested the effect of unilateral STN‐DBS on the performance of ipsilateral sequential movements and compared it with the performance of contralateral sequential movements. Three‐dimensional movements were recorded with the ELITE system and three kinematic variables were considered: total movement time (TMT), total inter‐onset latency (IOL), and spatial accuracy. Unilateral STN‐DBS significantly decreased TMT in the contralateral arm and only tended to do so also in the ipsilateral arm, whereas it significantly decreased IOL and worsened spatial accuracy only on the contralateral side. Before unilateral STN‐DBS a positive correlation was present between the clinical impairment and the TMTs in the contralateral and ipsilateral sides. After unilateral STN‐DBS the UPDRS scores improved in the contralateral and to a lesser extent also in the ipsilateral side. Correlation analysis between clinical and kinematic data showed no differences between the contralateral and ipsilateral sides. Our kinematic findings show that after STN‐DBS parkinsonian patients' performance of a sequential motor task improves significantly on the contralateral but only tended to do so on the ipsilateral side. 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In this study in unmedicated parkinsonian patients, we tested the effect of unilateral STN‐DBS on the performance of ipsilateral sequential movements and compared it with the performance of contralateral sequential movements. Three‐dimensional movements were recorded with the ELITE system and three kinematic variables were considered: total movement time (TMT), total inter‐onset latency (IOL), and spatial accuracy. Unilateral STN‐DBS significantly decreased TMT in the contralateral arm and only tended to do so also in the ipsilateral arm, whereas it significantly decreased IOL and worsened spatial accuracy only on the contralateral side. Before unilateral STN‐DBS a positive correlation was present between the clinical impairment and the TMTs in the contralateral and ipsilateral sides. After unilateral STN‐DBS the UPDRS scores improved in the contralateral and to a lesser extent also in the ipsilateral side. Correlation analysis between clinical and kinematic data showed no differences between the contralateral and ipsilateral sides. Our kinematic findings show that after STN‐DBS parkinsonian patients' performance of a sequential motor task improves significantly on the contralateral but only tended to do so on the ipsilateral side. 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href="file:MDS.MDS22203.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="4"></count><count type="tableTotal" number="1"></count><count type="referenceTotal" number="28"></count><count type="wordTotal" number="4622"></count></countGroup><titleGroup><title type="main" xml:lang="en">Ipsilateral sequential arm movements after unilateral subthalamic deep‐brain stimulation in patients with Parkinson's disease<link href="#fn2"></link></title><title type="short" xml:lang="en">Sequential Movements After Unilateral DBS in PD</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Rocco</givenNames><familyName>Agostino</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Loredana</givenNames><familyName>Dinapoli</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Nicola</givenNames><familyName>Modugno</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Ennio</givenNames><familyName>Iezzi</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Bruno</givenNames><familyName>Gregori</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Vincenzo</givenNames><familyName>Esposito</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Pantaleo</givenNames><familyName>Romanelli</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af1 #af2" corresponding="yes"><personName><givenNames>Alfredo</givenNames><familyName>Berardelli</familyName><degrees>MD</degrees></personName><contactDetails><email>alfredo.berardelli@uniroma1.it</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="IT" type="organization"><unparsedAffiliation>Neuromed Institute, “Sapienza,” University of Rome, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="IT" type="organization"><unparsedAffiliation>Department of Neurological Sciences, “Sapienza,” University of Rome, Italy</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">subthalamic nucleus</keyword><keyword xml:id="kwd2">deep brain stimulation</keyword><keyword xml:id="kwd3">sequential arm movements</keyword><keyword xml:id="kwd4">Parkinson's disease</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Unilateral STN‐DBS significantly improves the performance of contralateral sequential arm movements. Whether unilateral STN‐DBS also improves ipsilateral sequential movement is unclear. In this study in unmedicated parkinsonian patients, we tested the effect of unilateral STN‐DBS on the performance of ipsilateral sequential movements and compared it with the performance of contralateral sequential movements. Three‐dimensional movements were recorded with the ELITE system and three kinematic variables were considered: total movement time (TMT), total inter‐onset latency (IOL), and spatial accuracy. Unilateral STN‐DBS significantly decreased TMT in the contralateral arm and only tended to do so also in the ipsilateral arm, whereas it significantly decreased IOL and worsened spatial accuracy only on the contralateral side. Before unilateral STN‐DBS a positive correlation was present between the clinical impairment and the TMTs in the contralateral and ipsilateral sides. After unilateral STN‐DBS the UPDRS scores improved in the contralateral and to a lesser extent also in the ipsilateral side. Correlation analysis between clinical and kinematic data showed no differences between the contralateral and ipsilateral sides. Our kinematic findings show that after STN‐DBS parkinsonian patients' performance of a sequential motor task improves significantly on the contralateral but only tended to do so on the ipsilateral side. Ipsilateral changes can be explained by the observation that the output structures of the basal ganglia send large ipsilateral and less dense contralateral projections to the thalamus. © 2008 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn2"><p>Potential conflict of interest: None reported.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Ipsilateral sequential arm movements after unilateral subthalamic deep‐brain stimulation in patients with Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Sequential Movements After Unilateral DBS in PD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Ipsilateral sequential arm movements after unilateral subthalamic deep‐brain stimulation in patients with Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Rocco</namePart><namePart type="family">Agostino</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neuromed Institute, “Sapienza,” University of Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Loredana</namePart><namePart type="family">Dinapoli</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Neuromed Institute, “Sapienza,” University of Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nicola</namePart><namePart type="family">Modugno</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neuromed Institute, “Sapienza,” University of Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ennio</namePart><namePart type="family">Iezzi</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neuromed Institute, “Sapienza,” University of Rome, Italy</affiliation><affiliation>Department of Neurological Sciences, “Sapienza,” University of Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Bruno</namePart><namePart type="family">Gregori</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurological Sciences, “Sapienza,” University of Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Vincenzo</namePart><namePart type="family">Esposito</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neuromed Institute, “Sapienza,” University of Rome, Italy</affiliation><affiliation>Department of Neurological Sciences, “Sapienza,” University of Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pantaleo</namePart><namePart type="family">Romanelli</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neuromed Institute, “Sapienza,” University of Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alfredo</namePart><namePart type="family">Berardelli</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neuromed Institute, “Sapienza,” University of Rome, Italy</affiliation><affiliation>Department of Neurological Sciences, “Sapienza,” University of Rome, Italy</affiliation><description>Correspondence: Professor of Neurology, Department of Neurological Sciences and Neuromed Institute, “Sapienza,” University of Rome “Viale dell'Università 30, 00185 Rome, Italy</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2008-09-15</dateIssued><dateCaptured encoding="w3cdtf">2008-04-04</dateCaptured><dateValid encoding="w3cdtf">2008-06-09</dateValid><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">4</extent><extent unit="tables">1</extent><extent unit="references">28</extent><extent unit="words">4622</extent></physicalDescription><abstract lang="en">Unilateral STN‐DBS significantly improves the performance of contralateral sequential arm movements. Whether unilateral STN‐DBS also improves ipsilateral sequential movement is unclear. In this study in unmedicated parkinsonian patients, we tested the effect of unilateral STN‐DBS on the performance of ipsilateral sequential movements and compared it with the performance of contralateral sequential movements. Three‐dimensional movements were recorded with the ELITE system and three kinematic variables were considered: total movement time (TMT), total inter‐onset latency (IOL), and spatial accuracy. Unilateral STN‐DBS significantly decreased TMT in the contralateral arm and only tended to do so also in the ipsilateral arm, whereas it significantly decreased IOL and worsened spatial accuracy only on the contralateral side. Before unilateral STN‐DBS a positive correlation was present between the clinical impairment and the TMTs in the contralateral and ipsilateral sides. After unilateral STN‐DBS the UPDRS scores improved in the contralateral and to a lesser extent also in the ipsilateral side. Correlation analysis between clinical and kinematic data showed no differences between the contralateral and ipsilateral sides. Our kinematic findings show that after STN‐DBS parkinsonian patients' performance of a sequential motor task improves significantly on the contralateral but only tended to do so on the ipsilateral side. Ipsilateral changes can be explained by the observation that the output structures of the basal ganglia send large ipsilateral and less dense contralateral projections to the thalamus. © 2008 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: None reported.</note><subject lang="en"><genre>Keywords</genre><topic>subthalamic nucleus</topic><topic>deep brain stimulation</topic><topic>sequential arm movements</topic><topic>Parkinson's disease</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>23</number></detail><detail type="issue"><caption>no.</caption><number>12</number></detail><extent unit="pages"><start>1718</start><end>1724</end><total>7</total></extent></part></relatedItem><identifier type="istex">D52E8E76FF893E88357C0E9E3FB5E862A50FB030</identifier><identifier type="DOI">10.1002/mds.22203</identifier><identifier type="ArticleID">MDS22203</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2008 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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